TY  - JOUR
TI  - The RNA-binding protein Xp54nrb isolated from a Ca<SUP>2+</SUP>-dependent screen is expressed in neural structures during <I>Xenopus laevis</I> development
AU  - Neant, Isabelle
AU  - Deisig, Nina
AU  - Scerbo, Pierluigi
AU  - Leclerc, Catherine
AU  - Moreau, Marc
T2  - The International Journal of Developmental Biology
AB  - In amphibian embryos, calcium (Ca2+) signalling is a necessary and sufficient event to induce neural fate. Transient elevations of [Ca2+]i are recorded in neural tissue precursor cells in whole embryos during gastrulation. Using a subtractive cDNA library between control ectoderm (animal caps) and ectoderm induced toward a neural fate by Ca2+ release, we have isolated several Ca2+-induced target genes. Among the isolated genes, Xp54nrb encodes a protein which exhibits the RRM domains characteristic of RNA binding proteins, and is implicated in pre-mRNA splicing steps. Here we show that the Xp54nrb transcripts are expressed throughout early developmental stages, specifically in the neural and sensorial territories and that Xp54nrb could be involved in anterior neural patterning.
PY  - 2011
DO  - 10.1387/ijdb.103253in
VL  - 55
IS  - 10-11-12
SP  - 923
EP  - 931
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/103253in
Y2  - 2024/11/22/00:17:10
ER  -