TY  - JOUR
TI  - Escape mechanisms after antiangiogenic treatment, or why are the tumors growing again?
AU  - Hlushchuk, Ruslan
AU  - Makanya, AndrewN.
AU  - Djonov, Valentin
T2  - The International Journal of Developmental Biology
AB  - Inhibitors of angiogenesis and radiation induce compensatory changes in the tumor vasculature both during and after cessation of treatment. In numerous preclinical studies, angiogenesis inhibitors were shown to be efficient in the treatment of many pathological conditions, including solid cancers. In most clinical trials, however, this approach turned out to have no significant effect, especially if applied as monotherapy. Recovery of tumors after therapy is a major problem in the management of cancer patients. The mechanisms underlying tumor recovery (or therapy resistance) have not yet been explicitly elucidated. This review deals with the transient switch from sprouting to intussusceptive angiogenesis, which may be an adaptive response of tumor vasculature to cancer therapy that allows the vasculature to maintain its functional properties. Potential candidates for molecular targeting of this angioadaptive mechanism are yet to be elucidated in order to improve the currently poor efficacy of contemporary antiangiogenic therapies.
PY  - 2011
DO  - 10.1387/ijdb.103231rh
VL  - 55
IS  - 4-5
SP  - 563
EP  - 567
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/103231rh
Y2  - 2024/11/23/13:19:13
ER  -