TY - JOUR TI - The interplay between macrophages and angiogenesis in development, tissue injury and regeneration AU - Nucera, Silvia AU - Biziato, Daniela AU - De Palma, Michele T2 - The International Journal of Developmental Biology AB - During organ development and remodeling, macrophages support angiogenesis, not only by secreting proangiogenic growth factors and matrix-remodeling proteases, but also by physically interacting with the sprouting vasculature to assist the formation of complex vascular networks. Recent data further indicate that embryonic and tumor-associated macrophages express similar genetic programs, possibly suggesting convergent functions in organogenesis and tumorigenesis. In this article, we review the role of macrophages in development, tissue injury and regeneration, by focusing on the mechanisms used by subsets of these cells, such as the TIE2-expressing macrophages, to regulate angiogenesis and lymphangiogenesis in both fetal and post-natal life. PY - 2011 DO - 10.1387/ijdb.103227sn VL - 55 IS - 4-5 SP - 495 EP - 503 J2 - Int. J. Dev. Biol. LA - en SN - 0214-6282 SN - 1696-3547 UR - https://ijdb.ehu.eus/article/103227sn Y2 - 2024/10/16/04:02:21 ER -