TY  - JOUR
TI  - The interplay between macrophages and angiogenesis in development, tissue injury and regeneration
AU  - Nucera, Silvia
AU  - Biziato, Daniela
AU  - De Palma, Michele
T2  - The International Journal of Developmental Biology
AB  - During organ development and remodeling, macrophages support angiogenesis, not only by secreting proangiogenic growth factors and matrix-remodeling proteases, but also by physically interacting with the sprouting vasculature to assist the formation of complex vascular networks. Recent data further indicate that embryonic and tumor-associated macrophages express similar genetic programs, possibly suggesting convergent functions in organogenesis and tumorigenesis. In this article, we review the role of macrophages in development, tissue injury and regeneration, by focusing on the mechanisms used by subsets of these cells, such as the TIE2-expressing macrophages,  to regulate angiogenesis and lymphangiogenesis in both fetal and post-natal life.
PY  - 2011
DO  - 10.1387/ijdb.103227sn
VL  - 55
IS  - 4-5
SP  - 495
EP  - 503
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/103227sn
Y2  - 2024/11/21/18:11:13
ER  -