TY  - JOUR
TI  - Tryptase and chymase are angiogenic <I>in vivo</I> in the chorioallantoic membrane assay
AU  - Ribatti, Domenico
AU  - Ranieri, Girolamo
AU  - Nico, Beatrice
AU  - Benagiano, Vincenzo
AU  - Crivellato, Enrico
T2  - The International Journal of Developmental Biology
AB  - Human mast cells (MCs) are divided in two types depending on the expression of tryptase and chymase in their granules. Literature data indicate that both tryptase and chymase are angiogenic, but there is currently no evidence of their direct angiogenic activity in vivo. In this study, we have investigated the capacity of tryptase and chymase to promote vasoproliferation in chick embryo chorioallantoic membrane (CAM), a well established in vivo assay to study angiogenesis and anti-angiogenesis. The results showed that both tryptase and chymase stimulate angiogenesis and that the response is similar to that obtained with vascular endothelial growth factor (VEGF), a well-known angiogenic cytokine, and confirm the angiogenic activity of these two proteases stored in MC granules.
PY  - 2011
DO  - 10.1387/ijdb.103138dr
VL  - 55
IS  - 1
SP  - 99
EP  - 102
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/103138dr
Y2  - 2024/11/21/19:07:38
ER  -