TY  - JOUR
TI  - The transcriptional coactivators <I>Yap</I> and <I>TAZ</I>  are expressed during early <I>Xenopus</I> development 
AU  - Nejigane, Susumu
AU  - Haramoto, Yoshikazu
AU  - Okuno, Makoto
AU  - Takahashi, Shuji
AU  - Asashima, Makoto
T2  - The International Journal of Developmental Biology
AB  - The Yap and TAZ genes encode highly conserved domains which bind various transcription factors. Yap and TAZ act as transcriptional coactivators to modulate transcriptional activity. The activities of Yap and TAZ are negatively regulated by Hippo signaling via direct phosphorylation. In this study, we describe the expression patterns of Yap and TAZ during the development of Xenopus tropicalis. The Xenopus tropicalis Yap (xtYap) and Xenopus tropicalis TAZ (xtTAZ) genes are expressed maternally. xtYap is widely expressed throughout embryogenesis, particularly in the facial connective tissues, branchial arch, midbrain-hindbrain boundary, otic vesicle, pronephros, notochord, hindgut and tailbud. xtTAZ expression occurs predominantly in the presomitic mesoderm, facial connective tissues, brain, branchial arch, trunk neural crest cells and migrating hypaxial myoblasts. In the muscle lineage, xtTAZ expression is transient and restricted to proliferating cells, the presomitic mesoderm and the edges of the hypaxial myoblasts, with no expression detected in mature muscle cells. These results provide insights into the functions of Yap and TAZ and their regulation by Hippo signaling during early development in Xenopus.
PY  - 2011
DO  - 10.1387/ijdb.103130sn
VL  - 55
IS  - 1
SP  - 121
EP  - 126
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/103130sn
Y2  - 2024/12/28/17:22:45
ER  -