TY  - JOUR
TI  - Embryonic origin of human hematopoiesis
AU  - Tavian, Manuela
AU  - Biasch, Katia
AU  - Sinka, Lidia
AU  - Vallet, Judith
AU  - Péault, Bruno
T2  - The International Journal of Developmental Biology
AB  - Hematopoietic stem cells (HSC) are at the origin of the adult hematopoietic system. They give rise to all blood cells through a complex series of proliferation and differentiation events that occur throughout the lifespan of the individual. Because of their potential clinical importance in transplantation, recent research has focused on the developmental origins of embryonic HSC. During development in vertebrate embryos, two independent anatomical sites generate hematopoietic cells. The yolk sac is responsible for a first ephemeral hematopoiesis, characterized by the early appearance of hematopoietic progenitors with limited development ability that rapidly differentiate toward erythro-myeloid lineages. Self-renewing, multipotent adult-type HSC that also exhibit B and T lymphoid potentials emerge autonomously in the aorta/gonad/mesonephros (AGM) region inside the embryo. In this review, we provide a brief summary of recent developments regarding the origins of hematopoietic stem cells in the early human embryo. The recent discovery that angiotensin-converting enzyme (ACE) is a novel cell surface marker of human HSC is discussed in detail.
PY  - 2010
DO  - 10.1387/ijdb.103097mt
VL  - 54
IS  - 6-7
SP  - 1061
EP  - 1065
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/103097mt
Y2  - 2024/11/25/07:02:30
ER  -