TY  - JOUR
TI  - The deubiquitylating enzyme Cops6 regulates different developmental processes during early zebrafish embryogenesis
AU  - Tse, WilliamK.F.
AU  - You, May-Su
AU  - Ho, Steven Hao-Kee
AU  - Jiang, Yun-Jin
T2  - The International Journal of Developmental Biology
AB  - Zebrafish cops6 encodes a putative deubiquitylating enzyme (DUB) that belongs to the JAMM family. It consists of 297 amino acids and includes the Mov34/MPN/PAD-1 (PF01398) domain. Ubiquitylation is involved in many cellular processes and deconjugation of ubiquitin-modified substrates is important to maintain a sufficient amount of free ubiquitin in the cell. Here, we report our findings regarding the general function of the cops6 gene, as a continuation of our previous studies involving DUB knockdown screening. We have found that cops6 plays different roles in early embryonic development in the zebrafish, including dorsoventral patterning, convergent extension movement and brain formation. In addition, our findings indicate that cops6 plays an anti-apoptotic role during segmentation. Overall, the present study that consolidates our previous work on zebrafish DUB genes, corroborates the hypothesis of multi-functional roles for DUB genes during development.
PY  - 2011
DO  - 10.1387/ijdb.103089wt
VL  - 55
IS  - 1
SP  - 19
EP  - 24
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/103089wt
Y2  - 2024/12/22/07:51:27
ER  -