TY  - JOUR
TI  - Hematopoietic stem cell development in the placenta
AU  - Gekas, Christos
AU  - Rhodes, KatrinE.
AU  - Vanhandel, Ben
AU  - Chhabra, Akanksha
AU  - Ueno, Masaya
AU  - Mikkola, HannaK. A.
T2  - The International Journal of Developmental Biology
AB  - The placenta is a highly vascularized organ that mediates fetal-maternal exchange during pregnancy and is thereby vital for the survival and growth of the developing embryo. In addition to having this well-established role in supporting pregnancy, the placenta was recently shown to function as a hematopoietic organ. The placenta is unique among other fetal hematopoietic organs, as it is capable of both generating multipotential hematopoietic cells de novo and establishing a major hematopoietic stem cell (HSC) pool in the conceptus, while protecting HSCs from premature differentiation. The mouse placenta contains two distinct vascular regions that support hematopoiesis: the large vessels in the chorionic plate where HSCs/progenitors are thought to emerge and the labyrinth vasculature where nascent HSCs/progenitors may colonize for expansion and possible functional maturation. Defining how this cytokine- and growth factor rich organ supports HSC generation, maturation and expansion may ultimately help to establish culture protocols for HSC expansion or de novo generation from pluripotent cells.
PY  - 2010
DO  - 10.1387/ijdb.103070cg
VL  - 54
IS  - 6-7
SP  - 1089
EP  - 1098
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/103070cg
Y2  - 2024/11/05/11:25:09
ER  -