TY  - JOUR
TI  - Increased cellular turnover in response to fluoxetine in neuronal precursors derived from human embryonic stem cells 
AU  - Chang, Eun-Ah
AU  - Beyhan, Zeki
AU  - Yoo, Myung-Sik
AU  - Siripattarapravat, Kannika
AU  - Ko, Tak
AU  - Lookingland, KeithJ.
AU  - Madhukar, BurraV.
AU  - Cibelli, JoseB.
T2  - The International Journal of Developmental Biology
AB  - Previous reports have shown that antidepressants increase neuronal cell proliferation and enhance neuroplasticity both in vivo and in vitro. This study investigated the direct effects of one such antidepressant, fluoxetine , on cell proliferation and on the production of neurotrophic factors in neuronal precursors derived from human embryonic stem cells (hESCs; H9). Fluoxetine induced the differentiation of neuronal precursors, strongly enhancing neuronal characteristics. The rate of proliferation was higher in fluoxetine -treated cells than in control cells, as determined by MTT [3(4,5-dimethylthiazol-2-yl) 2,5-diphenyltetrazolium bromide] assay. The CPDL (cumulative population doubling level) of the fluoxetine-treated cells was significantly increased in comparison to that of control cells (p
PY  - 2010
DO  - 10.1387/ijdb.092851ec
VL  - 54
IS  - 4
SP  - 707
EP  - 715
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/092851ec
Y2  - 2024/11/21/23:25:16
ER  -