TY  - JOUR
TI  - Regulating the acrosome reaction
AU  - Florman, HarveyM.
AU  - Jungnickel, MelissaK.
AU  - Sutton, KeithA.
T2  - The International Journal of Developmental Biology
AB  - The acrosome reaction is a secretory event that must be completed by the sperm of many animal species prior to fusion with eggs. In mammals, exocytosis in triggered by ZP3, a glycoprotein component of the egg pellucida, following gamete contact. ZP3 promotes a sustained influx of Ca2+ into sperm that is necessary for the acrosome reaction. Here, we discuss the mechanism by which ZP3 generates Ca2+ entry, as well as the upstream events leading to this influx and downstream processes that couple it with exocytosis.
PY  - 2008
DO  - 10.1387/ijdb.082696hf
VL  - 52
IS  - 5-6
SP  - 503
EP  - 510
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/082696hf
Y2  - 2024/12/22/03:55:15
ER  -