TY  - JOUR
TI  - Role of polycomb proteins Ring1A and Ring1Bin the epigenetic regulation of gene expression 
AU  - Vidal, Miguel
T2  - The International Journal of Developmental Biology
AB  - Generation of cell diversity depends on epigenetic regulatory mechanisms. Polycomb group (PcG) proteins are central components of epigenetic regulation in metazoans. The system, initially associated with transcriptional program stability during development, is also involved in the regulation of other processes, such as maintenance of stem cell pluripotency and cell proliferation. PcG regulation involves chromatin modifications through covalent histone modifications. One of these modifications, the monoubiquitylation of the H2A histone, depends on Ring1 proteins, which are essential for development in insects and mammals. In murine embryonic stem cells, Ring1A and Ring1B-dependent ubiquitylation of H2A is linked to repression of transcriptional initiation. Studies in mammalian cells have found a multiplicity of protein complexes containing Ring1A and Ring1B, suggesting an expanded regulatory role for Ring1A, Ring1B proteins in the epigenetic regulation of gene expression.
PY  - 2009
DO  - 10.1387/ijdb.082690mv
VL  - 53
IS  - 2-3
SP  - 355
EP  - 370
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/082690mv
Y2  - 2024/12/22/04:09:45
ER  -