TY  - JOUR
TI  - Many paths to one goal? The proteins that recognize methylated DNA in eukaryotes 
AU  - Sasai, Nobuhiro
AU  - Defossez, Pierre-Antoine
T2  - The International Journal of Developmental Biology
AB  - DNA methylation is an epigenetically inherited chemical modification that is associated with transcriptional silencing and is essential for mammalian development. The DNA methylation signal is read out by methyl-CpG binding proteins (MBPs) that specifically bind to methylated DNA. Three structurally divergent families of MBPs have been identified so far: the MBD family, the SRA family and a family of proteins with Zinc fingers. In this review, we describe how the distinct families of methyl-CpG binding proteins have evolved, how they each recognize and maintain the DNA methylation mark, and finally how they turn this mark into biological effect.
PY  - 2009
DO  - 10.1387/ijdb.082652ns
VL  - 53
IS  - 2-3
SP  - 323
EP  - 334
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/082652ns
Y2  - 2024/11/23/13:05:30
ER  -