TY  - JOUR
TI  - Histone deacetylase 1 and 2-controlled embryonic development and cell differentiation
AU  - Brunmeir, Reinhard
AU  - Lagger, Sabine
AU  - Seiser, Christian
T2  - The International Journal of Developmental Biology
AB  - During development from the fertilized egg to a multicellular organism, cell fate decisions have to be taken and cell lineage or tissue-specific gene expression patterns are created and maintained. These alterations in gene expression occur in the context of chromatin structure and are controlled by chromatin modifying enzymes. Gene disruption studies in different genetic systems have shown an essential role of various histone deacetylases (HDACs) during early development and cellular differentiation. In this review, we focus on the functions of the class I enzymes HDAC1 and HDAC2 during development in different organisms and summarise the current knowledge about their involvement in neurogenesis, myogenesis, haematopoiesis and epithelial cell differentiation.
PY  - 2009
DO  - 10.1387/ijdb.082649rb
VL  - 53
IS  - 2-3
SP  - 275
EP  - 289
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/082649rb
Y2  - 2024/11/21/18:42:18
ER  -