TY  - JOUR
TI  - Identification of Quantitative Trait Loci responsible for embryonic lethality in mice assessed by ultrasonography 
AU  - Laissue, Paul
AU  - Burgio, Gaétan
AU  - l'Hote, David
AU  - Renault, Gilles
AU  - Marchiol-Fournigault, Carmen
AU  - Fradelizi, Didier
AU  - Fellous, Marc
AU  - Serres, Catherine
AU  - Montagutelli, Xavier
AU  - Monget, Philippe
AU  - Vaiman, Daniel
T2  - The International Journal of Developmental Biology
AB  - Recurrent Spontaneous Abortion (RSA) is a frequent pathology affecting 1 to 5% of couples. In ~50 % of cases, the aetiology is unknown suggesting a subtle interaction between genetic and environmental factors. Previous attempts to describe genetic factors using the candidate gene approach have been relatively unsuccessful due to the physiological, cellular and genetic complexity of mammalian reproduction. Indeed, fertility can be considered as a quantitative feature resulting from the interaction of genetic, epigenetic and environmental factors. Herein, we identified Quantitative Trait Loci (QTL) associated with diverse embryonic lethality phenotypes and the subsequent embryonic resorption in 39 inter-specific recombinant congenic mice strains, using in vivo ultrasound bio-microscopy. The short chromosomal intervals related to the phenotypes will facilitate the study of a restricted number of candidate genes which are potentially dysregulated in patients affected by RSA.
PY  - 2009
DO  - 10.1387/ijdb.082613pl
VL  - 53
IS  - 4
SP  - 623
EP  - 629
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/082613pl
Y2  - 2024/11/05/17:20:22
ER  -