TY  - JOUR
TI  - Ion channels that control fertility in mammalian spermatozoa
AU  - Navarro, Betsy
AU  - Kirichok, Yuriy
AU  - Chung, Jean-Ju
AU  - Clapham, DavidE.
T2  - The International Journal of Developmental Biology
AB  - Whole-cell voltage clamp of mammalian spermatozoa was first achieved in 2006. This technical advance, combined with genetic deletion strategies, makes unambiguous identification of sperm ion channel currents possible. This review summarizes the ion channel currents that have been directly measured in mammalian sperm, and their physiological roles in fertilization. The predominant currents are a Ca2+-selective current requiring expression of the 4 mCatSper genes, and a rectifying K+ current with properties most similar to mSlo3. Intracellular alkalinization activates both channels and induces hyperactivated motility.
PY  - 2008
DO  - 10.1387/ijdb.072554bn
VL  - 52
IS  - 5-6
SP  - 607
EP  - 613
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/072554bn
Y2  - 2024/11/05/15:26:49
ER  -