TY  - JOUR
TI  - Expression dynamics of the LIM-homeobox genes, <I>Lhx1</I> and <I>Lhx9</I>, in the diencephalon during chick development
AU  - Sun, Xiangnan
AU  - Saitsu, Hirotomo
AU  - Shiota, Kohei
AU  - Ishibashi, Makoto
T2  - The International Journal of Developmental Biology
AB  - The diencephalon is the caudal part of the developing forebrain, which corresponds to prosomeres 1 to 3. The mature diencephalon is functionally and anatomically divided into well-defined nuclei. Previous researches have shown that LIM-homeobox genes are important transcription factors during diencephalon regionalization in mice. Here we examined expression patterns of several chick orthologs of LIM-homeobox genes. Lhx1 and Lhx9 were expressed in the diencephalon from early stages and their expression in the diencephalon became restricted to prosomeres 1 and 2 in distinct fashions. Then we also studied the regulatory effects of possible upstream signals by in ovo electroporation. Lhx1 was found to be up-regulated by Shh signaling. Whereas Lhx9 was up-regulated by Wnt3a and Fgf15, it was down-regulated by Shh. Our data suggest that the LIM-homeobox genes, Lhx1 and Lhx9, regulated by ventral and/or dorsal signals, may play important roles in controlling regionalization of the diencephalon during chick development.
PY  - 2008
DO  - 10.1387/ijdb.072386xs
VL  - 52
IS  - 1
SP  - 33
EP  - 41
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/072386xs
Y2  - 2024/11/21/18:59:42
ER  -