TY  - JOUR
TI  - Hindbrain signals in otic regionalization: walk on the wild side
AU  - Schneider-Maunoury, Sylvie
AU  - Pujades, Cristina
T2  - The International Journal of Developmental Biology
AB  - The inner ear, the sensory organ responsible for hearing and balance, contains specialized sensory and non-sensory epithelia arranged in a highly complex three-dimensional structure. To achieve this level of complexity, a tight coordination between morphogenesis and cell fate specification is essential during otic development. Tissues surrounding the otic primordium and more particularly the adjacent segmented hindbrain, have been implicated in conferring signals required for inner ear development. In this review, we present the current view on the role of hindbrain signals in axial specification of the inner ear. The functional analysis of mutants of hindbrain segmentation genes, as well as the investigation of signaling pathways potentially involved, all point to an essential role of FGF, Wnt and Hh signaling in otic regionalization. However, these data provide conflicting evidence regarding the involvement of hindbrain signals in otic regionalization in fish and in amniotes. We discuss the possible origin of these differences.
PY  - 2007
DO  - 10.1387/ijdb.072345ss
VL  - 51
IS  - 6-7
SP  - 495
EP  - 506
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/072345ss
Y2  - 2024/11/21/18:48:15
ER  -