TY  - JOUR
TI  - PBX proteins: much more than Hox cofactors
AU  - Laurent, Audrey
AU  - Bihan, Réjane
AU  - Omilli, Francis
AU  - Deschamps, Stéphane
AU  - Pellerin, Isabelle
T2  - The International Journal of Developmental Biology
AB  - Pre-B cell leukaemia transcription factors (PBXs) were originally identified as Hox cofactors, acting within transcriptional regulation complexes to regulate genetic programs during development. Increasing amount of evidence revealed that PBX function is not restricted to a partnership with Hox or homeodomain proteins. Indeed, PBXs are expressed throughout murine embryonic development and are involved in several developmental pathways including Hox-independent mechanisms. This review summarizes what is known about PBX partnerships and proposes to position PBXs as central developmental factors whose role consists of integrating transduction signals, in order to regulate gene expression programs during development.
PY  - 2008
DO  - 10.1387/ijdb.072304al
VL  - 52
IS  - 1
SP  - 9
EP  - 20
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/072304al
Y2  - 2024/11/22/03:10:49
ER  -