TY  - JOUR
TI  - Generating asymmetries in the early vertebrate embryo: the role of the Cerberus-like family 
AU  - Belo, JoséA.
AU  - Silva, AnaC.
AU  - Borges, AnaC.
AU  - Filipe, Mário
AU  - Bento, Margaret
AU  - Gonçalves, Lisa
AU  - Vitorino, Marta
AU  - Salgueiro, Ana-marisa
AU  - Texeira, Vera
AU  - Tavares, AnaT.
AU  - Marques, Sara
T2  - The International Journal of Developmental Biology
AB  - One fundamental aspect of vertebrate embryonic development is the formation of the body plan. For this process, asymmetries have to be generated during early stages of development along the three main body axes: Anterior-Posterior, Dorso-Ventral and Left-Right. We have been studying the role of a novel class of molecules, the Cerberus/Dan gene family. These are dedicated secreted antagonists of three major signaling pathways: Nodal, BMP and Wnt. Our studies contribute to the current view that the fine tuning of signaling is controlled by a set of inhibitory molecules rather than by activators. In this context, the Cerberus-like molecules emerge as key players in the regulation and generation of asymmetries in the early vertebrate embryo.
PY  - 2009
DO  - 10.1387/ijdb.072297jb
VL  - 53
IS  - 8-9-10
SP  - 1399
EP  - 1407
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/072297jb
Y2  - 2024/11/27/06:18:01
ER  -