TY  - JOUR
TI  - Isolation, genomic structure and developmental expression of <I>Fgf8</I> in the short-tailed fruit bat, <I>Carollia perspicillata</I>
AU  - Cretekos, ChrisJ.
AU  - Deng, Jian-min
AU  - Green, EricD.
AU  - Nisc Comparative Sequencing Program, 
AU  - Rasweiler, JohnJ.
AU  - Behringer, RichardR.
T2  - The International Journal of Developmental Biology
AB  - Fibroblast growth factor-8 (Fgf8) encodes a secreted protein which was initially identified as the factor responsible for androgen-dependant growth of mouse mammary carcinoma cells (Tanaka et al., 1992). Fgf8 has been subsequently implicated in the patterning and growth of the gastrulating embryo, paraxial mesoderm (somites), limbs, craniofacial tissues, central nervous system and other organ systems during the development of several vertebrate model animals. Consistent with these findings, Fgf8 is expressed in a complex and dynamic pattern during vertebrate embryogenesis. Here we report the isolation and characterization of a bat (Carollia perspicillata) Fgf8 orthologue. Compared with those of other model vertebrates, Carollia Fgf8 is conserved with respect to genomic structure, sequence and many domains of developmental expression pattern. Interestingly, the expression domain marking the apical ectodermal ridge of the developing limb shows a striking difference compared to that of mouse, consistent with evolutionary diversification of bat limb morphology.
PY  - 2007
DO  - 10.1387/ijdb.062257cc
VL  - 51
IS  - 4
SP  - 333
EP  - 338
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/062257cc
Y2  - 2024/11/05/13:17:03
ER  -