TY  - JOUR
TI  - Expression and regulation of <I>Xenopus CRMP-4</I> in the developing nervous system
AU  - Souopgui, Jacob
AU  - Klisch, TiemoJ.
AU  - Pieler, Tomas
AU  - Henningfeld, KristineA.
T2  - The International Journal of Developmental Biology
AB  - The collaspin response mediator proteins (CRMPs) are a family of cytosolic phosphoproteins which play a critical role in the establishment of neuronal polarity and growth cone guidance. Here, we describe the temporal and spatial expression of CRMP-4 during early Xenopus embryogenesis. CRMP-4 transcripts were first detected by whole mount in situ hybridization at the end of gastrulation in the prospective neuroectoderm. During open neural plate stages, CRMP-4 was expressed broadly throughout the anterior neural plate and in the three bilateral stripes of the posterior neural plate where primary neurons arise. The expression in the territories of primary neurogenesis prefigures that of the post-mitotic neuronal marker N-tubulin. At tadpole stages, expression was maintained throughout the central nervous system and in the retina of the eye. Consistent with the observed expression, CRMP-4 transcripts are positively regulated by X-ngnr-1 and negatively by Notch signaling. The observed expression and regulation of CRMP-4 differ from that of the CRMP-2, which is induced by the events of neural induction.
PY  - 2007
DO  - 10.1387/ijdb.062235js
VL  - 51
IS  - 4
SP  - 339
EP  - 343
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/062235js
Y2  - 2024/11/05/17:17:39
ER  -