TY - JOUR TI - Retinal ganglion cells: dying to survive AU - Guerin, MarcB. AU - Mckernan, DeclanP. AU - O'Brien, ColmJ. AU - Cotter, ThomasG. T2 - The International Journal of Developmental Biology AB - This review examines the maturation of the retinal ganglion cell (RGC) population within the nascent retina. Apoptosis, a form of programmed cell death prevalent throughout the developing central nervous system (CNS), is evident in the growth of RGCs within the ganglion cell layer. These cells provide an accessible and illuminating platform to elucidate the apoptotic pathways present in the developing CNS and the role this form of cell death plays in RGC growth. This article focuses on the seminal stages of RGC development and the role played by neurotrophic factors and apoptosis in this process. PY - 2006 DO - 10.1387/ijdb.062159mg VL - 50 IS - 8 SP - 665 EP - 674 J2 - Int. J. Dev. Biol. LA - en SN - 0214-6282 SN - 1696-3547 UR - https://ijdb.ehu.eus/article/062159mg Y2 - 2024/12/14/03:52:27 ER -