TY - JOUR TI - The role of XTRAP-gamma in Xenopus pronephros development AU - Li, Dong-Hui AU - Chan, Techuan AU - Satow, Reiko AU - Komazaki, Shinji AU - Hashizume, Kouhei AU - Asashima, Makoto T2 - The International Journal of Developmental Biology AB - We isolated and characterized the Xenopus translocon-associated protein XTRAP-gamma, one of four subunits of the translocon-associated protein complex. TRAP has been proposed to aid the translocation of nascent polypeptides into the lumen of the endoplasmic reticulum, but this has not been demonstrated until now. XTRAP-gamma was specifically expressed in the pronephros tubules of Xenopus laevis from stage 25 during kidney development. Antisense morpholino oligonucleotide-mediated knockdown of XTRAP-gamma suppressed tubulogenesis and decreased expression of the pronephros marker genes Pax-2 and Wnt-4. XTRAP-gamma morpholinos also inhibited differentiation of the pronephros in activin/retinoic acid-treated animal caps. We conclude that XTRAP-gamma plays an important role in the process of pronephros differentiation. PY - 2005 DO - 10.1387/ijdb.052005dl VL - 49 IS - 4 SP - 401 EP - 408 J2 - Int. J. Dev. Biol. LA - en SN - 0214-6282 SN - 1696-3547 UR - https://ijdb.ehu.eus/article/052005dl Y2 - 2024/11/21/18:09:34 ER -