TY  - JOUR
TI  - The role of <I>XTRAP-gamma</I> in <I>Xenopus</I>  pronephros development
AU  - Li, Dong-Hui
AU  - Chan, Techuan
AU  - Satow, Reiko
AU  - Komazaki, Shinji
AU  - Hashizume, Kouhei
AU  - Asashima, Makoto
T2  - The International Journal of Developmental Biology
AB  - We isolated and characterized the Xenopus  translocon-associated protein XTRAP-gamma, one of four subunits of the translocon-associated protein complex. TRAP has been proposed to aid the translocation of nascent polypeptides into the lumen of the endoplasmic reticulum, but this has not been demonstrated until now. XTRAP-gamma  was specifically expressed in the pronephros tubules of Xenopus laevis  from stage 25 during kidney development. Antisense morpholino oligonucleotide-mediated knockdown of XTRAP-gamma  suppressed tubulogenesis and decreased expression of the pronephros marker genes Pax-2  and Wnt-4. XTRAP-gamma  morpholinos also inhibited differentiation of the pronephros in activin/retinoic acid-treated animal caps.  We conclude that XTRAP-gamma  plays an important role in the process of pronephros differentiation.
PY  - 2005
DO  - 10.1387/ijdb.052005dl
VL  - 49
IS  - 4
SP  - 401
EP  - 408
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/052005dl
Y2  - 2024/12/22/05:22:09
ER  -