TY  - JOUR
TI  - Development and function of bombesin-like peptides and their receptors
AU  - Ohki-Hamazaki, Hiroko
AU  - Iwabuchi, Maiko
AU  - Maekawa, Fumihiko
T2  - The International Journal of Developmental Biology
AB  - Amphibian bombesin and its related peptides consist a family of neuropeptides in many vertebrate species. Bombesin and two major bombesin-like peptide in mammals, gastrin-releasing peptide (GRP) and neuromedin B (NMB), have been shown to elicit various physiological effects. These include inhibition of feeding, smooth muscle contraction, exocrine and endocrine secretions, thermoregulation, blood pressure and sucrose regulations and cell growth. Receptors for GRP and NMB (GRP-R and NMB-R), as well as third subtype of bombesin-like peptide receptor (BRS-3) have been cloned. These receptors are G-protein-coupled receptors and are expressed in various brain regions and in the digestive tract. In this paper, we will summarize studies on these peptides and their receptors, with special reference to research using gene-knockout mice. These studies clearly demonstrated the role of three receptors in vivo  and in vitro. We will also discuss the phylogeny of these receptors.
PY  - 2005
DO  - 10.1387/ijdb.041954ho
VL  - 49
IS  - 2-3
SP  - 293
EP  - 300
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/041954ho
Y2  - 2024/11/24/07:08:38
ER  -