TY  - JOUR
TI  - Regulation of vertebrate eye development by <i>Rx </i>genes
AU  - Bailey, TravisJ.
AU  - El-Hodiri, Heithem
AU  - Zhang, Li
AU  - Shah, Rina
AU  - Mathers, EterH.
AU  - Jamrich, Milan
T2  - The International Journal of Developmental Biology
AB  - The paired-like homeobox-containing gene Rx has a critical role in the eye development of several vertebrate species including Xenopus, mouse, chicken, medaka, zebrafish and human. Rx is initially expressed in the anterior neural region of developing embryos, and later in the retina and ventral hypothalamus. Abnormal regulation or function of Rx results in severe abnormalities of eye formation. Overexpression of Rx in Xenopus and zebrafish embryos leads 
to overproliferation of retinal cells. A targeted elimination of Rx in mice results in a lack of eye formation. Mutations in Rx genes are the cause of the mouse mutation 
eyeless (ey1), the medaka temperature sensitive mutation eyeless (el) and the zebrafish mutation chokh. 
In humans, mutations in Rx lead to anophthalmia. All of these studies indicate that Rx genes are key factors in vertebrate eye formation. Because these results cannot be easily reconciled with the most popular dogmas of the field, we offer our interpretation of eye development and evolution.
PY  - 2004
DO  - 10.1387/ijdb.041878tb
VL  - 48
IS  - 8-9
SP  - 761
EP  - 770
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/041878tb
Y2  - 2024/12/22/12:23:04
ER  -