TY  - JOUR
TI  - <I>MMTV-trBrca1 </I>mice display strain-dependent abnormalities in vaginal development
AU  - Simpson, KayleneJ.
T2  - The International Journal of Developmental Biology
AB  - The breast cancer susceptibility gene Brca1 encodes a large multi-functional 
protein which is implicated as a caretaker of the genome, through its role in regulation of DNA 
damage response pathways, including apoptosis. Here we show that in mice expressing a 
dominant-negative Brca1 transgene on a BALB/c background, vaginal entrance remodeling is inhibited, and that the incidence of this phenotype is increased on a p53 +/- genotype. Given that this developmental process is mediated primarily by apoptosis, we hypothesized that disruption of BRCA1 may confer a resistance to apoptosis in normal epithelial cells. Consistent with this, we show that expression of this transgene in vitro leads to resistance to ionizing radiation induced cell killing in mammary epithelial cells. This is the first time that BRCA1 has been implicated in an apoptosis-mediated normal developmental process.

PY  - 2004
DO  - 10.1387/ijdb.041849ks
VL  - 48
IS  - 7
SP  - 675
EP  - 678
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/041849ks
Y2  - 2024/11/21/23:21:07
ER  -