TY  - JOUR
TI  - Activin-like signaling activates Notch signaling during mesodermal induction
AU  - Abe, Takanori
AU  - Furue, Miho
AU  - Myoishi, Yasufumi
AU  - Okamoto, Tetsuji
AU  - Kondow, Akiko
AU  - Asashima, Makoto
T2  - The International Journal of Developmental Biology
AB  - Both activin-like signaling and Notch signaling play fundamental roles during early development. Activin-like signaling is involved in mesodermal induction and can induce a broad range of mesodermal genes and tissues from prospective ectodermal cells (animal caps). On the other hand, Notch signaling plays important roles when multipotent precursor cells achieve a specific cell fate. However, the relationship between these two signal pathways is not well understood. Here, we show that activin A induces Delta-1, Delta-2 and Notch expression and then activates Notch signaling in animal caps. Also, in vivo, ectopic activin-like signaling induced the ectopic expression of Delta-1 and Delta-2, whereas inhibition of activin-like signaling abolished the expression of Delta-1 and Delta-2. Furthermore, we show that MyoD, which is myogenic gene induced by activin A, can induce Delta-1 expression. However, MyoD had no effect on Notch expression, and inhibited Delta-2 expression. These results indicated that activin A induces Delta-1, Delta-2 and Notch by different cascades. We conclude that Notch signaling is activated when activin-like signaling induces various tissues from homogenous undifferentiated cells.
PY  - 2004
DO  - 10.1387/ijdb.041838ta
VL  - 48
IS  - 4
SP  - 327
EP  - 332
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/041838ta
Y2  - 2024/11/05/17:20:19
ER  -