TY  - JOUR
TI  - Tumor invasion and metastasis: getting more basic to come closer to the patient. An interview with Lance A. Liotta.
AU  - Castronovo, Vincent
T2  - The International Journal of Developmental Biology
AB  - Lance Liotta, M.D., Ph.D. is one of the pioneers who opened, in 
the 1970s, a major new alley of investigation in the field of 
cancer research: the study of the mechanisms which sustain 
tumor invasion and metastasis. Using his outstanding creative mind 
and his expertise in biomedical engineering, he has proposed over 
the years powerful, innovative concepts which have inspired the 
whole scientific community in the field of cancer. He is the author of 
the three step model for tumor invasion (degradation, adhesion 
and migration of cancer cells) which has guided and enlightened 
tens if not hundreds of researchers, leading to incredible progress in 
our understanding of the mechanisms used by malignant cells 
to progress during their walk from the primary tumor to the 
deadly secondary colonies. With his colleagues, he invented Laser 
Capture Microdissection (LCM), an ingenious apparatus used today 
in more than 500 laboratories worldwide, which has enabled 
researchers to explore for the first time, the real time events 
occurring during cancer progression. One of his last achievements, 
among many, is a novel Drosophila model which can be 
genetically manipulated to study the key genetic events underlying 
tumor invasion and metastases.

PY  - 2004
DO  - 10.1387/ijdb.041834vc
VL  - 48
IS  - 5-6
SP  - 559
EP  - 562
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/041834vc
Y2  - 2024/11/23/11:45:07
ER  -