TY  - JOUR
TI  - Primordial germ cell migration
AU  - Molyneaux, Kathleen
AU  - Wylie, Christopher
T2  - The International Journal of Developmental Biology
AB  - Mutational and antisense screens in Drosophila and zebrafish, and transcriptional profiling and time-lapse analysis in the mouse, have contributed greatly to our understanding of PGC development. In all three systems, the behavior of PGCs is controlled by growth factors 
which signal through G-protein coupled receptors and/or tyrosine kinase receptors. Additionally, 
regulated cell-cell and cell-substrate adhesion is important for PGC motility. Finally, localized 
growth factors may control PGC survival and consequently PGC position. Chemotaxis, regulated 
adhesion and cell survival are important for multiple migration processes which occur during 
development and disease. PGC migration shares these features.

PY  - 2004
DO  - 10.1387/ijdb.041833km
VL  - 48
IS  - 5-6
SP  - 537
EP  - 543
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/041833km
Y2  - 2024/11/24/03:20:32
ER  -