TY  - JOUR
TI  - The Wnt connection to tumorigenesis
AU  - Behrens, Jurgen
AU  - Lustig, Barbara
T2  - The International Journal of Developmental Biology
AB  - Wnt signaling has been identified as one of the key signaling pathways in 
cancer, regulating cell growth, motility and differentiation. Because of its widespread activation in diverse human tumor diseases, the Wnt pathway has gained considerable and growing interest in 
tumor research over recent years. Evidence that altered Wnt signaling is important for human 
tumor development came from three major findings: (i) the tumor suppressor adenomatous polyposis 
coli (APC) binds to the Wnt pathway component β-catenin and is involved in its degradation, 
(ii) mutations of APC in colon tumors lead to stabilization of the β-catenin protein and (iii) tumor-associated mutations of β-catenin in colorectal cancer as well as in other tumor types lead to its stabilisation, qualifying β-catenin as a proto-oncogene. Here we will describe the biochemical interactions which shape the Wnt pathway and focus on its role in tumorigenesis.
PY  - 2004
DO  - 10.1387/ijdb.041815jb
VL  - 48
IS  - 5-6
SP  - 477
EP  - 487
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/041815jb
Y2  - 2024/12/21/17:23:36
ER  -