TY  - JOUR
TI  - Cytoskeletal mechanisms responsible for invasive migration of neoplastic cells
AU  - Vasiliev, JuryM.
T2  - The International Journal of Developmental Biology
AB  - Cytoskeletal reorganizations, especially alterations of contractile tension 
generated by the actin-myosin cortex, are of central importance in the development of the phenotype 
of morphologically transformed neoplastic cells with invasive behavior. These reorganizations 
can be regarded as genetically determined aberrations of the physiological reactions of normal 
cells which are responsible for their ability to undergo exploratory migrations, including 
epithelio-mesenchymal transformations, invasion of matrix by epithelial tubules 
etc. It is suggested that these physiological and neoplastic transformations are based on Rho-dependent alterations in contractility. A decrease or an increase in contractility may result in the development of distinct types of invasive phenotypes. These contractility-dependent phenotype alterations may be modified by alterations in the expression of other genes, especially of those coding for components of adhesive structures.
PY  - 2004
DO  - 10.1387/ijdb.041806jv
VL  - 48
IS  - 5-6
SP  - 425
EP  - 439
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/041806jv
Y2  - 2024/11/25/07:09:23
ER  -