TY  - JOUR
TI  - Distinctive expression of <I>Myf5 </I>in relation to differentiation 
and plasticity of newt muscle cells
AU  - Imokawa, Yutaka
AU  - Gates, PhillipB.
AU  - Chang, Young-tae
AU  - Simon, Hans-Georg
AU  - Brockes, JeremyP.
T2  - The International Journal of Developmental Biology
AB  - Regeneration in urodele amphibians such as the newt reflects the local plasticity 
of differentiated cells. Newt myotubes and myofibres undergo S phase re-entry and 
cellularisation in the limb blastema, and we have analysed the regulation of 
Myf5 in relation to these events. Surprisingly, 
Myf5 was expressed after fusion in cultured newt myotubes and in myofibers of 
the adult limb, in contrast to its familiar expression in myoblasts in other vertebrates.  Its 
expression was markedly down regulated in cultured newt myotubes after S phase re-entry induced by 
serum stimulation, as well as by exposure to the trisubstituted purine called myoseverin which 
induces cellularisation.  We have attempted to relate this striking difference from other vertebrates to 
the requirement for multinucleate urodele muscle cells to contribute to the regeneration blastema.
PY  - 2004
DO  - 10.1387/ijdb.031787yi
VL  - 48
IS  - 4
SP  - 285
EP  - 291
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/031787yi
Y2  - 2024/04/25/07:43:42
ER  -