TY  - JOUR
TI  - The regulation of homothorax and the control of eye-head proportion in Drosophila
AU  - Bessa, J
AU  - Casares, F
T2  - The International Journal of Developmental Biology
AB  - In the fruit fly Drosophila melanogaster, eye and head grow up to a constant, species-specific, size proportion. Eye and head originate from the same pool of cells, so the correct number of cells must be allocated to one of either fate during development. Two signaling pathways are instrumental in this allocation: wingless (wg) promotes head while decapentaplegic (dpp) promotes eye. Key to understand how eye and head growth is coordinated is to find the genes these two antagonizing signaling pathways act upon. One of these genes seems to be the transcription factor homothorax (hth). In the absence of hth, the head capsule does not develop and ectopic eye tissue forms. Here we present data showing that wg and dpp signaling might be independently activating and repressing hth, respectively. The nuclear factor Dac is required for hth repression downstream of dpp.
PY  - 2001
VL  - 45
IS  - S1
SP  - S135
EP  - S136
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/01450135
Y2  - 2024/11/24/15:15:19
ER  -