TY  - JOUR
TI  - FGF signalling and blastema growth during amphibian tail regeneration
AU  - Ferretti, P
AU  - Zhang, F
AU  - Santos-Ruiz, L
AU  - Clarke, JDW
T2  - The International Journal of Developmental Biology
AB  - Urodeles amphibians can regenerate their tails, including spinal cord and ganglia, as adults. The cellular and molecular mechanisms underlying tail regeneration, and particularly recruitment of neural progenitors and the initiation of their division have yet to be fully elucidated. We have studied the role of FGF2 in this process and found that FGF2 is important both for regeneration of the spinal cord and of the mesenchymal tissues of the tail stump, as indicated by its up-regulation in the blastema and in ependymal cells and by the fact that FGF2-soaked beads increase blastema growth as compared to controls. We have also studied the expression of Pleurodeles Sox1 in regenerating tails, as members of this gene family have been shown to be upstream of FGF signalling in other systems. We show by RT-PCR analysis that this gene is expressed at low levels in normal tail, suggesting that its presence in the adult newt tail may be causally related to its high regenerative capability. Furthermore, this gene is significantly up-regulated following tail amputation indicating that it plays an important role during tail regeneration.
PY  - 2001
VL  - 45
IS  - S1
SP  - S127
EP  - S128
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/01450127
Y2  - 2024/11/05/15:23:07
ER  -