TY  - JOUR
TI  - D-4 and D-1/D-5 dopamine receptors interact synergistically in the rat striatum
AU  - Trias, S
AU  - Rivera, A
AU  - Megias, M
AU  - Penafiel, A
AU  - Marin-Giron, F
AU  - De la Calle, A
T2  - The International Journal of Developmental Biology
AB  - D1-like (D-1 and D-5) and D-2-like (D-2, D-3 and D-4) dopamine receptor subtypes interact synergistically in many paradigms, such as dopamine (DA) agonist-stimulated motor behaviour and striatal c-Fos expression in intact and DA-depleted striatum. However, it is not clear which subtypes of dopamine receptor are involved in these process. We now report the implication of D-4 receptor in D1/D2 interactions by examining the effects of the D-1/D-5 agonist SKF 38393 and the D-4 agonist PID 168,077 on the expression of c-Fos in rats with unilateral 6-Hydroxydopamine(6-OHDA) lesions of the nigroestriatal pathway. Systemic administration of PD 168,077 led to a higher dose-dependent induction of c-Fos in the lesioned striatum as compared with the contralateral portion. In all cases, c-Fos expression pattern was heterogeneous, being more abundant in the medial part. A low dose of SKF 38393 or PID 168,077 alone produce little induction of c-Fos, but combination of both agonists produced a synergistic effect on c-Fos expression. In this case c-Fos-positive nuclei pattern was heterogeneous in the latero-medial axis and occurred primarily in patches. Furthermore, we have demonstrated that activated cells are medium-sized projecting neurons. This finding suggest that D-4 dopamine receptors play an important role in D1/D2 interactions occurred in an animal model of Parkinson's disease.
PY  - 2001
VL  - 45
IS  - S1
SP  - S93
EP  - S94
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/01450093
Y2  - 2024/11/05/15:27:11
ER  -