TY  - JOUR
TI  - OI-KIP, a cyclin dependent kinase inhibitor, is expressed in developing and adult brain of the Medaka (Oryzias latipes)
AU  - Suarez, EMC
AU  - Nguyen, V
AU  - Joly, JS
AU  - Bourrat, F
T2  - The International Journal of Developmental Biology
AB  - We have isolated OI-KIP, anew member of CIP/ KIP family of cyclin-dependent kinase inhibitors (CDIs), from an expression screen in the medaka (Teleost), and then analyzed its expression pattern in developing and adult brain by in situ hybridization (ISH). To better define the expression profile of this CDI during cell differentiation, we performed a double labeling with OI-KIP mRNA and antibodies against proliferating cell nuclear antigen (PCNA). In the optic tectum, expression of RNA encoding OI-KIP during early embryogenesis is largely associated with the start of cell differentiation in proliferative zones; later in development, its expression is closely related to cell cycle exit. In the adult brain, transcripts appeared also in postmitotic cells long after they have exited the cell cycle. So, they may play a role in maintenance of the quiescent state throughout life.
PY  - 2001
VL  - 45
IS  - S1
SP  - S71
EP  - S72
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/01450071
Y2  - 2024/11/05/15:26:43
ER  -